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Statistical analysis was performed with SPSS version 21.0 (IBM Corp., Armonk, NY). Baseline characteristics between those patients with the outcome in question (neutropenia) versus those without this outcome were compared by Wilcoxon's rank sum or chi-square for continuous or dichotomous variables, respectively. Because of the low number of cases, we were unable to perform multivariable analysis to further explore risk factors for the development of neutropenia; thus, all analysis is descriptive in nature.

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A total of 49 patients received ceftaroline therapy between June 2012 and December 2014. Of these patients, 39 received greater than 7 days of ceftaroline therapy. Baseline characteristics are listed in Table 1 . The median duration of therapy was 27 days, with a range of 9 to 125 days. In patients who did and did not develop neutropenia, the median durations of therapy were 23 days (25th to 75th percentile, 19.5 to 51.5) and 25.5 days (25th to 75th percentile, 14.25 to 38.25), respectively ( P = 0.755). Of note, the patient that received 125 days had a complicated disease course with a nonoperable spinal epidural abscess; this patient ultimately did develop neutropenia. The next-longest duration of therapy was 52 days. Figure 1 depicts a box plot of the durations of therapy.

View this table:
TABLE 1

Baseline characteristics of patients who did and did not develop neutropenia

View larger version:
FIG 1

Box plot of duration of therapy in those who became neutropenic and those who did not. = 0.755.

Seven patients developed neutropenia (ANC < 1,500 cells/mm 3 ). We did not detect significant changes in cell lines other than the neutrophil (lymphocytes, basophils, and eosinophils). Kaani linenblend cover up SU Designs Discount New Arrival Sale Cheap Prices Cheap Low Cost Original Cheap Online gj74jNMuC
depicts trends in these cell lines throughout the first 6 weeks of ceftaroline therapy. We noted wide fluctuations in the platelet counts of many patients; however, there was no correlation with ceftaroline therapy or its cessation (some patients developed transient thrombocytopenia [<150,000/mm 3 ] but recovered despite continuation of therapy).

View larger version:
FIG 2

Graphs of mean hemoglobin concentration (A), mean eosinophil count (B), mean lymphocyte count (C), and mean platelet count (D) by week in patients who did and did not become neutropenic through the course of therapy.

Twenty-six of the 32 patients who did not develop neutropenia initially received 600 mg of ceftaroline every 12 h. One patient, who had an orthopedic infection, received 600 mg every 8 h; the remaining 5 patients received lower doses due to impaired renal function. Three patients required additional dose adjustment during treatment due to changes in renal function. Of the seven patients who did develop neutropenia, six of them received 600 mg of ceftaroline every 12 h; one, again with an orthopedic infection, received 600 mg every 8 h (q8h). None of these patients required dose adjustment or developed significant renal impairment throughout the duration of treatment.

Hahn said some of their best days were spent at Wrigley Field — McGovern was an avid Cubs fan — and they would sit and talk for hours.

Admiration also came from across the aisle. Democratic strategist Kitty Kurth, now president of political consulting firm Kurth Lampe, said McGovern was “always professional.”

“We would disagree on candidates and issues, but he was never disagreeable,” Kurth said. “He was an honorable man in politics, which, in this day and age, is hard to come by.”

McGovern’s cousin, Luke Lincoln, said the two were friends who grew up together in Lake Forest and attended the same schools since they were only a few years apart.

McGovern enjoyed fishing, hunting and golfing in his spare time. Chicago — and his beloved Cubs and Blackhawks — “had a special place in his heart,” Lincoln said.

“He was a great family man,” Lincoln said. “He was kind of old-school in that he liked tradition and history. He was the historian of our family.”

McGovern earned a bachelor’s degree in history and American studies from Princeton and then went on to receive a law degree from Northwestern University’s Pritzker School of Law.

Besides Kirk, Fitzgerald and Hastert, McGovern also served as spokesman for former Illinois Treasurer Judy Baar Topinka, as well as the Illinois Republican Party.

Beyond politics, McGovern served as president of the auxiliary board of The Art Institute of Chicago, and on the board of directors for the Boys Girls Clubs of Chicago and the Elawa Farm Foundation.

Last year, he joined the Thurston Group to manage several of the firm’s strategic priorities, and before that McGovern worked with Resolute Consulting, focusing on health care industry clients.

McGovern is survived by his wife Wentworth, two young sons, his mother Karen McGovern and his sister Courtney McGovern. Services are scheduled for 4:30 p.m. July 18 at theChurch of the Holy Spirit,400 E. Westminster Ave., in Lake Forest.

His family has asked that donations in memoriam be made to Deerfield Academy in Massachusetts, The Art Institute of Chicago, or Elawa Farm in Lake Forest.

Rachel Hinton
Email: rhinton@suntimes.com
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